Article
The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells.
The Journal of biological chemistry - 19 Jun 2009
D'mello Veera, Singh Sukhwinder, Wu Yi, Birge Raymond B
Abstract excerpt
The urokinase receptor (uPAR), expressed on the surface of many cell types, coordinates plasmin-mediated cell surface proteolysis for matrix remodeling and promotes cell adhesion by acting as a binding protein for vitronectin. There is great clinical interest in uPAR in the cancer field as numerous reports have demonstrated that up-regulation of the uPA system is correlated with malignancy of various carcinomas....
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