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Article

Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.

Molecular immunology - 1 Mar 2007

Kaartinen Tanja, Lappalainen Jani, Haimila Katri, Autero Matti, Partanen Jukka

Abstract excerpt

Genetic and functional studies suggest that polymorphism in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and inducible costimulator (ICOS) genes, both reported to harbour autoimmune susceptibility loci, could regulate the immune activation through affecting their expression and splicing of...

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Source

Identifiers

PMID: 16996590
DOI: 10.1016/j.molimm.2006.08.010

Genes

CTLA4
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16996590-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.PMID 16996590Read ↗

Genetic polymorphism of the human ICOS gene.Semantic proximity Read ↗

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Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.Semantic proximity Read ↗

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Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism.Semantic proximity Read ↗

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The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell FunctionSemantic proximity Read ↗

Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.Semantic proximity Read ↗

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