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Article

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution.

Journal of neuroimmunology - 1 May 2007

Castelli Luca, Comi Cristoforo, Chiocchetti Annalisa, Nicola Stefania, Mesturini Riccardo, Giordano Mara, D'Alfonso Sandra, Cerutti Elisa, Galimberti Daniela, Fenoglio Chiara, Tesser Fabiana, Yagi Junji, Rojo José Maria, Perla Franco, Leone Maurizio, Scarpini Elio, Monaco Francesco, Dianzani Umberto

Abstract excerpt

Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed...

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Share to 3' Untranslated Regions
Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inducible T-Cell Co-Stimulator Protein

Share to Interleukin-10

Share to Leukocytes, Mononuclear

Share to Linkage Disequilibrium

Share to Multiple Sclerosis

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Source

Identifiers

PMID: 17481737
DOI: 10.1016/j.jneuroim.2007.03.022

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution.PMID 17481737Read ↗

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