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Article

Modification of COMT-dependent pain sensitivity by psychological stress and sex.

Pain - 1 Apr 2016

Meloto Carolina B, Bortsov Andrey V, Bair Eric, Helgeson Erika, Ostrom Cara, Smith Shad B, Dubner Ronald, Slade Gary D, Fillingim Roger B, Greenspan Joel D, Ohrbach Richard, Maixner William, McLean Samuel A, Diatchenko Luda

Abstract excerpt

Catecholamine-O-methyltransferase (COMT) is a polymorphic gene whose variants affect enzymatic activity and pain sensitivity via adrenergic pathways. Although COMT represents one of the most studied genes in human pain genetics, findings regarding its association with pain phenotypes are not always replicated. Here, we investigated if interactions among functional COMT haplotypes, stress, and sex can modify the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26675825
DOI: 10.1097/j.pain.0000000000000449
PMCID: PMC4794347

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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