Article
Hypoxia induces metalloproteinase-9 activation and human vascular smooth muscle cell migration through low-density lipoprotein receptor-related protein 1-mediated Pyk2 phosphorylation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2013
Revuelta-López Elena, Castellano José, Roura Santiago, Gálvez-Montón Carolina, Nasarre Laura, Benitez Sonia, Bayes-Genis Antoni, Badimon Lina, Llorente-Cortés Vicenta
Abstract excerpt
OBJECTIVE: Hypoxia disturbs vascular function by promoting extracellular matrix remodeling. Extracellular matrix integrity and composition are modulated by metalloproteinases (MMPs). Our aim was to investigate the role of low-density lipoprotein receptor-related protein 1 (LRP1) in regulating MMP-9/MMP-2 activation and vascular smooth muscle cells (VSMCs) migration in response to hypoxia, and to elucidate the...
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