Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle.

American journal of physiology. Cell physiology - 1 Jun 2004

Somara Sita, Bitar Khalil N

Abstract excerpt

Displacement of the contractile protein tropomyosin from actin filament exposes the myosin-binding sites on actin, resulting in actin-myosin interaction and muscle contraction. The objective of the present study was to better understand the interaction of tropomyosin with heat shock protein (HSP)27 in contraction of smooth muscle cells of the colon. We investigated the possibility of a direct protein-protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Glutathione Transferase
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Myocytes, Smooth Muscle

Share to Rabbits

Share to Serine

Share to Tropomyosin

Source

Identifiers

PMID: 14749215
DOI: 10.1152/ajpcell.00458.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Tropomyosin interacts with phosphorylated HSP27 in agonist-induced contraction of smooth muscle.PMID 14749215Read ↗

Modulation of HSP27 alters hypoxia-induced endothelial permeability and related signaling pathways.Semantic proximity Read ↗

Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model.Semantic proximity Read ↗

Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction.Semantic proximity Read ↗

Identification of a novel actin binding motif in smooth muscle myosin light chain kinase.Semantic proximity Read ↗

Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa.Semantic proximity Read ↗

Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain.Semantic proximity Read ↗

Forced expression of essential myosin light chain isoforms demonstrates their role in smooth muscle force production.Semantic proximity Read ↗

Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide.Semantic proximity Read ↗

Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.