Article
Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.
The Journal of biological chemistry - 3 Jun 2005
McMullen Meghan E, Bryant Patrick W, Glembotski Christopher C, Vincent Peter A, Pumiglia Kevin M
Abstract excerpt
Pathological conditions such as hypertension and hyperglycemia as well as abrasions following balloon angioplasty all lead to endothelial dysfunction that impacts disease morbidity. These conditions are associated with the elaboration of a variety of cytokines and increases in p38 activity in endothelial cells. However, the relationship between enhanced p38 activity and endothelial cell function remains poorly...
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