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Dietary restriction suppresses proteotoxicity and enhances longevity by an <i>hsf‐1</i> ‐dependent mechanism in <i>Caenorhabditis elegans</i>

10 Mar 2008

Abstract excerpt

Dietary restriction increases lifespan and slows the onset of age-associated disease in organisms from yeast to mammals. In humans, several age-related diseases are associated with aberrant protein folding or aggregation, including neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases. We report here that dietary restriction dramatically suppresses age-associated paralysis in...

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PMID: 18331616
DOI: 10.1111/j.1474-9726.2008.00385.x

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