Article
Integration of evolutionary and desolvation energy analysis identifies functional sites in a plant immunity protein.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2009
Casasoli Manuela, Federici Luca, Spinelli Francesco, Di Matteo Adele, Vella Nicoletta, Scaloni Flavio, Fernandez-Recio Juan, Cervone Felice, De Lorenzo Giulia
Abstract excerpt
Plant immune responses often depend on leucine-rich repeat receptors that recognize microbe-associated molecular patterns or pathogen-specific virulence proteins, either directly or indirectly. When the recognition is direct, a molecular arms race takes place where plant receptors continually and rapidly evolve in response to virulence factor evolution. A useful model system to study ligand-receptor coevolution...
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