Article
LRR conservation mapping to predict functional sites within protein leucine-rich repeat domains.
PloS one - 1 Jan 2011
Helft Laura, Reddy Vignyan, Chen Xiyang, Koller Teresa, Federici Luca, Fernández-Recio Juan, Gupta Rishabh, Bent Andrew
Abstract excerpt
Computational prediction of protein functional sites can be a critical first step for analysis of large or complex proteins. Contemporary methods often require several homologous sequences and/or a known protein structure, but these resources are not available for many proteins. Leucine-rich repeats (LRRs) are ligand interaction domains found in numerous proteins across all taxonomic kingdoms, including immune...
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