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Article

Residue coevolution and mutational landscape for OmpR and NarL response regulator subfamilies.

Biophysical journal - 19 Mar 2024

Shibata Mayu, Lin Xingcheng, Onuchic José N, Yura Kei, Cheng Ryan R

Abstract excerpt

DNA-binding response regulators (DBRRs) are a broad class of proteins that operate in tandem with their partner kinase proteins to form two-component signal transduction systems in bacteria. Typical DBRRs are composed of two domains where the conserved N-terminal domain accepts transduced signals and the evolutionarily diverse C-terminal domain binds to DNA. These domains are assumed to be functionally...

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Identifiers

PMID: 38291753
DOI: 10.1016/j.bpj.2024.01.028
PMCID: PMC10995415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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