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Article

Surveying a local fitness landscape of a protein with epistatic sites for the study of directed evolution.

Biopolymers - 5 Jul 2002

Aita Takuyo, Hamamatsu Norio, Nomiya Yukiko, Uchiyama Hidefumi, Shibanaka Yasuhiko, Husimi Yuzuru

Abstract excerpt

We present a method for analysis of a fitness landscape of a biopolymer with significantly epistatic sites. The analysis is based on a quasi-additive fitness model. The fitness model is constructed with additive terms conducted by "site-fitness" and epistatic terms conducted by "pair-fitness," where the site-fitness is a fitness contribution from an independent residue and the pair-fitness is a fitness...

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PMID: 11979520
DOI: 10.1002/bip.10126

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