On the accuracy of inferring energetic coupling between distant sites in protein families from evolutionary imprints: illustrations using lattice model.

Abstract excerpt

It is suspected that correlated motions among a subset of spatially separated residues drive conformational dynamics not only in multidomain but also in single domain proteins. Sequence and structure-based methods have been proposed to determine covariation between two sites on a protein. The statistical coupling analysis (SCA) that compares the changes in probability at two sites in a multiple sequence alignment...

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• Binding Sites
• Evolution, Molecular
• Models, Molecular
• Mutation
• PDZ Domains