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Article

A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Stolz Ailine, Ertych Norman, Bastians Holger

Abstract excerpt

Proper regulation of microtubule dynamics during mitosis is essential for faithful chromosome segregation. In fact, recently we discovered increased microtubule plus end assembly rates that are frequently observed in human cancer cells as an important mechanism leading to whole chromosome missegregation and chromosomal instability (CIN). However, the genetic alterations responsible for increased microtubule...

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Share to Chromosomal Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25590964
DOI: 10.1080/15384101.2014.1000693
PMCID: PMC4614948

Genes

KIF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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