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Article

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

The EMBO journal - 21 Jun 2006

Draviam V M, Shapiro I, Aldridge B, Sorger P K

Abstract excerpt

The correct formation of stable but dynamic links between chromosomes and spindle microtubules (MTs) is essential for accurate chromosome segregation. However, the molecular mechanisms by which kinetochores bind MTs and checkpoints monitor this binding remain poorly understood. In this paper, we...

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Share to Adenomatous Polyposis Coli Protein
Share to Chromosome Segregation
Share to Chromosomes, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Kinetochores

Share to Metaphase

Share to Microtubule-Associated Proteins

Share to Nondisjunction, Genetic

Source

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Identifiers

PMID: 16763565
DOI: 10.1038/sj.emboj.7601168
PMCID: PMC1500857

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16763565-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.PMID 16763565Read ↗

APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.Semantic proximity Read ↗

CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.Semantic proximity Read ↗

Misaligned chromosomes that satisfy the spindle assembly checkpoint are a strong predictor of micronuclei formation in dividing cancer cellsSemantic proximity Read ↗

Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC.Semantic proximity Read ↗

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.Semantic proximity Read ↗

Molecular analysis of kinetochore-microtubule attachment in budding yeast.Semantic proximity Read ↗

XMAP215-EB1 interaction is required for proper spindle assembly and chromosome segregation in Xenopus egg extract.Semantic proximity Read ↗

Captivating capture: how microtubules attach to kinetochores.Semantic proximity Read ↗

Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.Semantic proximity Read ↗

Kinetochore-microtubule error correction is driven by differentially regulated interaction modes.Semantic proximity Read ↗

Mitotic spindle misorientation in cancer--out of alignment and into the fire.Semantic proximity Read ↗

Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization.Semantic proximity Read ↗

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