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Article

Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease.

Neuroscience letters - 23 Oct 2003

Poli Maura, Gatta Luisa Benerini, Archetti Silvana, Padovani Alessandro, Albertini Alberto, Finazzi Dario

Abstract excerpt

Recent biological studies indicate the importance of anterior-pharynx defective-1 (APH-1) proteins in Alzheimer's disease (AD) pathogenesis. We scanned APH-1 genes for the presence of sequence variations by denaturing high performance liquid chromatography and analyzed their distribution in an Italian sample of 113 AD patients and 132 controls. We found six different polymorphisms: three of them, all in APH-1b,...

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PMID: 12972157
DOI: 10.1016/s0304-3940(03)00857-7

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