Common GSAP promoter variant contributes to Alzheimer's disease liability.

Abstract excerpt

Toxic amyloid-β40-42 (Aβ40-42) peptide cleaved from Aβ protein precursor by β- and γ secretases plays a crucial role in the etiology of Alzheimer's disease (AD). Recently, Paul Greengard laboratory described a novel γ-secretase activating protein (gSAP) that specifically increases Aβ40-42 production without affecting the cleavage of another γ-secretase substrate, Notch. In this study, we show that expression of...

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