Article
Elevated MBL concentrations are not an indication of association between the MBL2 gene and type 1 diabetes or diabetic nephropathy.
Diabetes - 1 Jul 2009
Kaunisto Mari A, Sjölind Lisa, Sallinen Riitta, Pettersson-Fernholm Kim, Saraheimo Markku, Fröjdö Sara, Forsblom Carol, Fagerudd Johan, Hansen Troels K, Flyvbjerg Allan, Wessman Maija, Groop Per-Henrik
Abstract excerpt
OBJECTIVE: Mannose-binding lectin (MBL) is an essential component of the acute-phase immune response and may thus play a role in the pathogenesis of type 1 diabetes and diabetic nephropathy. The serum concentration of MBL is mainly genetically determined, and elevated concentrations have been associated with both type 1 diabetes and diabetic nephropathy. Previous genetic studies have not been conclusive due to...
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