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Article

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes.

Frontiers in immunology - 1 Jan 2022

Dørflinger G H, Høyem P H, Laugesen E, Østergaard J A, Funck K L, Steffensen R, Poulsen P L, Hansen T K, Bjerre M

Abstract excerpt

Introduction: Accumulating evidence support that mannan-binding lectin (MBL) is a promising prognostic biomarker for risk-stratification of diabetic micro- and macrovascular complications. Serum MBL levels are predominately genetically determined and depend on MBL genotype. However, Type 1 diabetes (T1D) is associated with higher MBL serum levels for a given MBL genotype, but it remains unknown if this is also...

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Identifiers

PMID: 36618347
DOI: 10.3389/fimmu.2022.1080388
PMCID: PMC9816478

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