Article
Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene.
Clinical and experimental immunology - 1 Jul 2017
Krogh S S, Holt C B, Steffensen R, Funck K L, Høyem P, Laugesen E, Poulsen P L, Thiel S, Hansen T K
Abstract excerpt
Mounting evidence indicates that adverse activation of the complement system plays a role in the development of diabetic vascular complications. Plasma levels of the complement proteins mannan-binding lectin (MBL) and its associated serine proteases (MASP-1 and MASP-2) are elevated in diabetes. We hypothesized that single nucleotide polymorphisms (SNPs) in the MASP1 gene may contribute to altered plasma levels of...
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