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Article

Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.

Oncotarget - 16 May 2017

Jiang Yannan, Qi Xinming, Liu Xinyu, Zhang Jun, Ji Jun, Zhu Zhenggang, Ren Jin, Yu Yingyan

Abstract excerpt

Fbxw7, a subunit of the SCF E3 ubiquitin ligase, recognizes oncoprotein substrates and leads to their proteasomal degradation. Fbxw7 acts as a tumor suppressor via inducing apoptosis and growth arrest in various kinds of tumors. To clarify the initiating role in gastric carcinogenesis as well as the histologic characterization of tumor in Fbxw7 allele haploinsufficient mice, we generated Fbxw7 heterozygous...

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Identifiers

PMID: 28422719
DOI: 10.18632/oncotarget.16800
PMCID: PMC5464881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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