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Article

Uracil-DNA glycosylases preferentially excise mispaired uracil.

The Biochemical journal - 1 Nov 1992

Verri A, Mazzarello P, Spadari S, Focher F

Abstract excerpt

We have investigated the substrate specificity of human, viral and bacterial uracil-DNA glycosylases employing as substrate double-stranded oligonucleotides containing in the same position of the 5'-32P-labelled strand an uracil residue facing, on the complementary strand, guanine (mimicking cytosine deamination) or adenine (mimicking dUTP misincorporation). The enzyme removal of uracil was monitored and...

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Identifiers

PMID: 1359874
DOI: 10.1042/bj2871007
PMCID: PMC1133107

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