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Article

Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.

Autism research : official journal of the International Society for Autism Research - 1 Jun 2008

Campbell Daniel B, Li Chun, Sutcliffe James S, Persico Antonio M, Levitt Pat

Abstract excerpt

A functional promoter variant of the gene encoding the MET receptor tyrosine kinase alters SP1 and SUB1 transcription factor binding, and is associated with autism spectrum disorder (ASD). Recent analyses of postmortem cerebral cortex from ASD patients revealed altered expression of MET protein and three transcripts encoding proteins that regulate MET signaling, hepatocyte growth factor (HGF), urokinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19360663
DOI: 10.1002/aur.27
PMCID: PMC2678909

Genes

MET
PLAUR
SERPINE1
HGF
SUB1

Provenance

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