Disruption of cerebral cortex MET signaling in autism spectrum disorder.

doi:10.1002/ana.21180

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Article

Disruption of cerebral cortex MET signaling in autism spectrum disorder.

Annals of neurology - 1 Sept 2007

Campbell Daniel B, D'Oronzio Rosanna, Garbett Krassi, Ebert Philip J, Mirnics Karoly, Levitt Pat, Persico Antonio M

Abstract excerpt

OBJECTIVE: Multiple genes contribute to autism spectrum disorder (ASD) susceptibility. One particularly promising candidate is the MET gene, which encodes a receptor tyrosine kinase that mediates hepatocyte growth factor (HGF) signaling in brain circuit formation, immune function, and gastrointestinal repair. The MET promoter variant rs1858830 allele "C" is strongly associated with ASD and results in reduced gene...

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PMID: 17696172
DOI: 10.1002/ana.21180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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