SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism.

doi:10.1016/j.bbrc.2007.06.051

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Article

SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism.

Biochemical and biophysical research communications - 7 Sept 2007

Toyoda Takao, Nakamura Kazuhiko, Yamada Kazuo, Thanseem Ismail, Anitha Ayyappan, Suda Shiro, Tsujii Masatsugu, Iwayama Yoshimi, Hattori Eiji, Toyota Tomoko, Miyachi Taishi, Iwata Yasuhide, Suzuki Katsuaki, Matsuzaki Hideo, Kawai Masayoshi, Sekine Yoshimoto, Tsuchiya Kenji, Sugihara Gen-ichi, Ouchi Yasuomi, Sugiyama Toshiro, Takei Nori, Yoshikawa Takeo, Mori Norio

Abstract excerpt

Autism is a pervasive neurodevelopmental disorder diagnosed in early childhood. Growth factors have been found to play a key role in the cellular differentiation and proliferation of the central and peripheral nervous systems. Epidermal growth factor (EGF) is detected in several regions of the developing and adult brain, where, it enhances the differentiation, maturation, and survival of a variety of neurons....

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PMID: 17626784
DOI: 10.1016/j.bbrc.2007.06.051

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