Article
Further evidence for the role of MET in autism susceptibility.
Neuroscience research - 1 Oct 2010
Thanseem Ismail, Nakamura Kazuhiko, Miyachi Taishi, Toyota Tomoko, Yamada Satoru, Tsujii Masatsugu, Tsuchiya Kenji J, Anitha Ayyappan, Iwayama Yoshimi, Yamada Kazuo, Hattori Eiji, Matsuzaki Hideo, Matsumoto Kaori, Iwata Yasuhide, Suzuki Katsuaki, Suda Shiro, Kawai Masayoshi, Sugihara Gen-Ichi, Takebayashi Kiyokazu, Takei Noriyoshi, Ichikawa Hironobu, Sugiyama Toshiro, Yoshikawa Takeo, Mori Norio
Abstract excerpt
MET receptor tyrosine kinase (MET)-mediated signaling has been implicated in multiple aspects of neocortical and cerebellar neuronal growth and maturation. A promoter functional SNP (rs1858830) that disrupts the transcription of MET has been reported to be strongly associated with autism spectrum disorders (ASD) in the Caucasian population. Here, we performed a trio association study of MET with ASD in Japanese...
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