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Article

Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.

Oncology reports - 1 May 2009

Winder Thomas, Mündlein Axel, Rhomberg Simone, Dirschmid Klaus, Hartmann Bernd L, Knauer Michael, Drexel Heinz, Wenzl Etienne, De Vries Alexander, Lang Alois

Abstract excerpt

A glycine to valine substitution at codon 12 (G12V) in Kirsten-Ras (K-Ras) gene has been associated with reduced overall survival in colorectal cancer patients; however, the effect of other K-Ras mutations than G12V still remains unclear. Therefore, we investigated the role of different K-Ras mutations on overall survival in a homogeneous, large patient cohort with standardized therapy and uniform analysis of...

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Identifiers

PMID: 19360305
DOI: 10.3892/or_00000352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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