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Article

Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.

Genetics - 1 Sept 2001

Lemieux J, Lakowski B, Webb A, Meng Y, Ubach A, Bussière F, Barnes T, Hekimi S

Abstract excerpt

We show that the phenotype associated with gro-1(e2400) comprises the whole suite of features that characterize the phenotype of the clk mutants in Caenorhabditis elegans, including deregulated developmental, behavioral, and reproductive rates, as well as increased life span and a maternal effect. We cloned gro-1 and found that it encodes a highly conserved cellular enzyme, isopentenylpyrophosphate:tRNA...

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Identifiers

PMID: 11560893
DOI: 10.1093/genetics/159.1.147
PMCID: PMC1461807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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