Article

In vivo serial passaging of human-simian immunodeficiency virus clones identifies viral characteristics that enhance persistent viral replication

2021-09-15

Abstract excerpt

We previously reported that a human immunodeficiency virus type 1 with a simian immunodeficiency virus vif substitution (HSIV-vifNL4-3) could replicate in pigtailed macaques (PTMs), demonstrating that Vif is a species-specific tropism factor of primate lentiviruses. However, infections did not result in high peak viremia or setpoint plasma viral loads, as observed during SIV infection of PTMs. Here, we characteri...

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Literature Corpus work: 756aef8a-fb68-56da-9230-6a18dd15c2a1
DOI: 10.1101/2021.09.15.460387

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In vivo serial passaging of human-simian immunodeficiency virus clones identifies viral characteristics that enhance persistent viral replicationDOI 10.1101/2021.09.15.460387Read

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