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High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

7 Apr 2009

Abstract excerpt

Integration of genetic and metabolic profiling holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolomic profiles has not been evaluated in humans. We performed quantitative mass spectrometry-based metabolic profiling in 117 individuals within eight multiplex families from the GENECARD study of premature CAD. Heritabilities...

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PMID: 19357637
DOI: 10.1038/msb.2009.11

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