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Article

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

PLoS genetics - 1 Nov 2015

Kraus William E, Muoio Deborah M, Stevens Robert, Craig Damian, Bain James R, Grass Elizabeth, Haynes Carol, Kwee Lydia, Qin Xuejun, Slentz Dorothy H, Krupp Deidre, Muehlbauer Michael, Hauser Elizabeth R, Gregory Simon G, Newgard Christopher B, Shah Svati H

Abstract excerpt

Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about the biological pathways that influence levels of most of these metabolites. Here, we analyzed genetics, epigenetics, and transcriptomics with metabolomics in samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26540294
DOI: 10.1371/journal.pgen.1005553
PMCID: PMC4634848

Genes

BRSK2
FBXO25
HERC1
HOOK2
SEL1L
STIM1
SUGT1
USP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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