Article
Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.
Molecular biology of the cell - 1 Jun 2009
Sivaramakrishnan Sivaraj, Schneider Jaime L, Sitikov Albert, Goldman Robert D, Ridge Karen M
Abstract excerpt
Keratin intermediate filaments (KIFs) form a fibrous polymer network that helps epithelial cells withstand external mechanical forces. Recently, we established a correlation between the structure of the KIF network and its local mechanical properties in alveolar epithelial cells. Shear stress applied across the cell surface resulted in the structural remodeling of KIF and a substantial increase in the elastic...
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