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Article

Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells.

Circulation research - 1 Apr 2005

Ganguli Arunima, Persson Linda, Palmer Ian R, Evans Iona, Yang Lin, Smallwood Rod, Black Richard, Qwarnstrom Eva E

Abstract excerpt

NF-kappaB, a transcription factor central to inflammatory regulation during development of atherosclerosis, is activated by soluble mediators and through biomechanical inputs such as flow-mediated shear- stress. To investigate the molecular mechanisms underlying shear stress mediated signal transduction in vascular cells we have developed a system that applies flow-mediated shear stress in a controlled manner,...

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PMID: 15731464
DOI: 10.1161/01.RES.0000160435.83210.95

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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