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Article

The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles.

Biomaterials - 1 Aug 2009

Atkins Gerald J, Welldon Katie J, Holding Christopher A, Haynes David R, Howie Donald W, Findlay David M

Abstract excerpt

Polyethylene (PE) wear particles are associated with the osteolysis seen in aseptic loosening that leads to orthopaedic implant failure. While cells of the monocyte/macrophage lineage are implicated, evidence is now emerging that osteoblastic cells may also be affected by PE. In this study we investigated the effect of PE particles on osteoblasts, using a novel in vitro cell culture system that was developed to...

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Identifiers

PMID: 19349075
DOI: 10.1016/j.biomaterials.2009.03.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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