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Article

Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2002

Wang Mark L, Nesti Leon J, Tuli Richard, Lazatin Jovin, Danielson Keith G, Sharkey Peter F, Tuan Rocky S

Abstract excerpt

Long-term stability of arthroplasty prosthesis depends on the integration between osseous tissue and the implant biomaterial. Integrity of the osseous tissue requires the contribution of mesenchymal stem cells and their continuous differentiation into an osteoblastic phenotype. This study aims to investigate the hypothesis that exposure to wear debris particles derived from orthopaedic biomaterials affects the...

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Source

Identifiers

PMID: 12472226
DOI: 10.1016/S0736-0266(02)00076-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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