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Article

An advanced tri-culture model to evaluate the dynamic interplay among osteoblasts, osteoclasts, and endothelial cells.

Journal of cellular physiology - 1 Jan 2018

Pagani Stefania, Torricelli Paola, Veronesi Francesca, Salamanna Francesca, Cepollaro Simona, Fini Milena

Abstract excerpt

The dynamic metabolism and the numerous roles of bone tissue necessitate a suitable in vitro model to represent them. In order to investigate the interaction among the several cell types composing bone microenvironment, we studied a tri-culture model including human osteoblasts (OBs), osteoclasts (OCs), and endothelial cells (HUVEC). While OBs are essential for bone deposition and OCs for bone resorption, the...

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Identifiers

PMID: 28240358
DOI: 10.1002/jcp.25875

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CTSK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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