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Article

Regulation of osteoclasts by osteoblast lineage cells depends on titanium implant surface properties.

Acta biomaterialia - 1 Mar 2018

Lotz Ethan M, Berger Michael B, Schwartz Zvi, Boyan Barbara D

Abstract excerpt

A critical stage during osseointegration of a titanium (Ti) implant is primary bone remodeling, which involves cross talk among osteoclast precursors, osteoclasts, mesenchymal stem cells (MSCs), and osteoblasts. This phase couples the processes of bone formation and resorption. During remodeling, osteoclasts produce factors capable of regulating MSC migration and osteogenesis. Furthermore, they degrade primary...

Topics

Cell Lineage
Cells, Cultured
Humans
Integrins
Osteoblasts
Osteoclasts
Osteoprotegerin
Phenotype
Prostheses and Implants
Surface Properties
Titanium
Transforming Growth Factor beta1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 29292169
DOI: 10.1016/j.actbio.2017.12.039
PMCID: PMC5803380

Genes

MSC
SLA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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