Article
Phagocytosis of wear debris by osteoblasts affects differentiation and local factor production in a manner dependent on particle composition.
Biomaterials - 1 Mar 2000
Lohmann C H, Schwartz Z, Köster G, Jahn U, Buchhorn G H, MacDougall M J, Casasola D, Liu Y, Sylvia V L, Dean D D, Boyan B D
Abstract excerpt
Wear debris is considered to be one of the main factors responsible for aseptic loosening of orthopaedic endoprostheses. Whereas the response of cells in the monocytic lineage to foreign materials has been extensively studied, little is known about cells at the bone formation site. In the present study, we examined the hypothesis that the response of osteoblasts to wear debris depends on the chemical composition...
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