Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Apr 2009

Atkins G J, Welldon K J, Halbout P, Findlay D M

Abstract excerpt

SUMMARY: The effect of strontium ranelate (SR) on human osteoblast differentiation was tested. SR induced osteoblastic proliferation, in vitro mineralization, and increased the expression of osteocyte markers. SR also elicited an osteoprotegerin (OPG) secretory response. We conclude that SR promotes the osteoblast maturation and osteocyte differentiation while promoting an additional antiresorptive effect....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Density Conservation Agents
Share to Calcification, Physiologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Organometallic Compounds

Share to Osteoblasts

Share to Osteocytes

Share to Osteoprotegerin

Share to Thiophenes

Source

Identifiers

PMID: 18763010
DOI: 10.1007/s00198-008-0728-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response.PMID 18763010Read ↗

RANKL expression is related to the differentiation state of human osteoblasts.Semantic proximity Read ↗

Calcium sensing receptor‐dependent and receptor‐independent activation of osteoblast replication and survival by strontium ranelateSemantic proximity Read ↗

Dose-dependent effects of strontium on osteoblast function and mineralization.Semantic proximity Read ↗

Osteogenesis in vitro: from pre-osteoblasts to osteocytes: a contribution from the Osteobiology Research Group, The Pennsylvania State University.Semantic proximity Read ↗

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosisSemantic proximity Read ↗

Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression.Semantic proximity Read ↗

Expression and function of the P2X7 receptor in human osteoblasts: The role of NFATc1 transcription factorSemantic proximity Read ↗

Dexamethasone, BMP-2, and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype: validation of an in vitro model for human bone marrow-derived primary osteoblasts.Semantic proximity Read ↗

The induction of a catabolic phenotype in human primary osteoblasts and osteocytes by polyethylene particles.Semantic proximity Read ↗

The effects of dexamethasone, ascorbic acid, and β-glycerophosphate on osteoblastic differentiation by regulating estrogen receptor and osteopontin expression.Semantic proximity Read ↗

The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitroSemantic proximity Read ↗

ER Gene Expression in Human Primary Osteoblasts: Evidence for the Expression of Two Receptor ProteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.