Article
Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 2001
Dean D D, Lohmann C H, Sylvia V L, Köster G, Liu Y, Schwartz Z, Boyan B D
Abstract excerpt
Periprosthetic osteolysis and implant loosening is associated with the presence of ultrahigh molecular weight polyethylene (UHMWPE) wear debris particles. Osteoblast phenotypic expression in vitro is affected by UHMWPE particles, suggesting that bone formation may also be affected by wear debris. Here we tested the hypothesis that the response of osteoblasts to UHMWPE can be modified by changes in UHMWPE particle...
Topics
- Alkaline Phosphatase
- Cell Count
- Cell Division
- Dinoprostone
- Dose-Response Relationship, Drug
- Drug Combinations
- Humans
- Molecular Weight
- Osteoblasts
- Particle Size
- Phenotype
- Polyethylenes
- Stearic Acids
- Tumor Cells, Cultured