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Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Brombacher Frank, Arendse Berenice, Peterson Reagon, Hölscher Alexandra, Hölscher Christoph

Abstract excerpt

Macrophage activation can be divided into a classical and an alternative pathway. Interferon-gamma-induced, classically activated macrophages are indispensable for protective effector responses against intracellular pathogens. However, excessive inflammatory immune responses mediated by classical macrophage activation can also be detrimental to the host. In contrast, the IL-4 receptor-alpha-mediated alternative...

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PMID: 19347321
DOI: 10.1007/978-1-59745-396-7_15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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