Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility.

Abstract excerpt

Rodents typically demonstrate strain-specific susceptibilities to induced autoimmune models such as experimental arthritis and encephalomyelitis. A common feature of the local pathology of these diseases is an extensive infiltration of activated macrophages (MPhi). Different functional activation states can be induced in MPhi during innate immune activation, and it is this differential activation that might be...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arginase
• Share to Autoimmune Diseases