Article
Human polymorphic variants of the NEIL1 DNA glycosylase.
The Journal of biological chemistry - 25 May 2007
Roy Laura M, Jaruga Pawel, Wood Thomas G, McCullough Amanda K, Dizdaroglu Miral, Lloyd R Stephen
Abstract excerpt
In mammalian cells, the repair of DNA bases that have been damaged by reactive oxygen species is primarily initiated by a series of DNA glycosylases that include OGG1, NTH1, NEIL1, and NEIL2. To explore the functional significance of NEIL1, we recently reported that neil1 knock-out and heterozygotic mice develop the majority of symptoms of metabolic syndrome (Vartanian, V., Lowell, B., Minko, I. G., Wood, T. G.,...
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