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Article

Association of polymorphism in the human mu-opioid receptor OPRM1 gene with proinflammatory cytokine levels and health perception.

Brain, behavior, and immunity - 1 Oct 2009

Matsunaga Masahiro, Isowa Tokiko, Murakami Hiroki, Kasugai Kunio, Yoneda Masashi, Kaneko Hiroshi, Ohira Hideki

Abstract excerpt

Recent studies in psychoneuroimmunology have indicated that proinflammatory cytokines cause several diseases and behaviors that overlap symptomatically with depression. It is known that the endogenous opioid peptide beta-endorphin regulates proinflammatory cytokine secretion from peripheral immune cells via mu-opioid receptor-dependent mechanisms. Therefore, it is possible that the functional polymorphism of the...

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Source

Identifiers

PMID: 19341791
DOI: 10.1016/j.bbi.2009.03.007

Genes

OPRM1
TNF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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