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Article

Regulation of mu-opioid receptors by cytokines

1 Jan 2009

Abstract excerpt

Opioids are the most potent analgesics. However, their clinical use is limited by side effects like respiratory depression and their high potential for abuse. In addition, they modulate immune functions and cause immunosuppression. Effects of clinically important opioids like morphine are mediated by the mu-opioid receptor. Knowledge about the mechanisms controling the expression of the mu-opioid receptor gene in...

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PMID: 19482692
DOI: 10.2741/s16

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