How variants in inflammatory mediator genes influence symptom severity of psychiatric disorders: Findings from the PsyCourse study.

doi:10.1016/j.psychres.2025.116492

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Article

How variants in inflammatory mediator genes influence symptom severity of psychiatric disorders: Findings from the PsyCourse study.

Psychiatry research - 1 Jun 2025

Oraki Kohshour Mojtaba, Adorjan Kristina, Budde Monika, Heilbronner Maria, Kalman Janos L, Navarro-Flores Alba, Reich-Erkelenz Daniela, Schulte Eva C, Senner Fanny, Vogl Thomas, Anghelescu Ion-George, Arolt Volker, Baune Bernhardt T, Dannlowski Udo, Dietrich Detlef E, Fallgatter Andreas J, Figge Christian, Lang Fabian U, Juckel Georg, Konrad Carsten, Reimer Jens, Reininghaus Eva Z, Schmauß Max, Schmitt Andrea, Spitzer Carsten, Wiltfang Jens, Zimmermann Jörg, Falkai Peter, Heilbronner Urs, Papiol Sergi, Schulze Thomas G

Abstract excerpt

Alterations in glial cell function and cytokine levels in the central nervous system may be influenced by neuroinflammatory processes, which have a pathogenic role in psychiatric disorders. Variability in genes that encode inflammatory mediators is associated with risk of developing mental disorders. Therefore, by analyzing data from the transdiagnostic PsyCourse Study, we aimed to investigate whether variations...

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Topics

Humans
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Adult

Middle Aged

Cross-Sectional Studies

Bipolar Disorder

Mental Disorders

Severity of Illness Index

Inflammation Mediators

Psychotic Disorders

Mania

Source

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Identifiers

PMID: 40239607
DOI: 10.1016/j.psychres.2025.116492

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