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Article

Amyloid beta-protein: experiment and theory on the 21-30 fragment.

The journal of physical chemistry. B - 30 Apr 2009

Murray Megan M, Krone Mary Griffin, Bernstein Summer L, Baumketner Andrij, Condron Margaret M, Lazo Noel D, Teplow David B, Wyttenbach Thomas, Shea Joan-Emma, Bowers Michael T

Abstract excerpt

The structure of the 21-30 fragment of the amyloid beta-protein (Abeta) was investigated by ion mobility mass spectrometry and replica exchange dynamics simulations. Mutations associated with familial Alzheimer's disease (E22G, E22Q, E22K, and D23N) of Abeta(21-30) were also studied, in order to understand any structural changes that might occur with these substitutions. The structure of the WT peptide shows a...

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Identifiers

PMID: 19341254
DOI: 10.1021/jp808384x
PMCID: PMC2693341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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