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Article

Changes to the structure and dynamics in mutations of Aβ(21-30) caused by ions in solution.

The journal of physical chemistry. B - 5 Dec 2013

Smith Micholas Dean, Cruz Luis

Abstract excerpt

The structure and dynamics of the 21-30 fragment of the amyloid β-protein (Aβ(21-30)) and its Dutch [Glu22Gln], Arctic [Glu22Gly], and Iowa [Asp23Asn] isoforms are of considerable importance, as their folding may play an important role in the pathogenesis of sporadic and familial forms of Alzheimer's disease and cerebral amyloid angiopathy. A full understanding of this pathologic folding in in vivo environments...

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Identifiers

PMID: 24261958
DOI: 10.1021/jp408579v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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