Effect of pathogenic mutations on the structure and dynamics of Alzheimer's A beta 42-amyloid oligomers.

Abstract excerpt

Converging lines of evidence suggest that soluble A beta-amyloid oligomers play a pivotal role in the pathogenesis of Alzheimer's disease, and present direct effectors of synaptic and cognitive dysfunction. Three pathological E22-A beta-amyloid point mutants (E22G, E22K, E22Q) and the deletion mutant E22 Delta exhibit an enhanced tendency to form prefibrillar aggregates. The present study assessed the effect of...

Topics

• Alzheimer Disease
• Amyloid
• Amyloid beta-Protein Precursor
• Humans
• Molecular Dynamics Simulation
• Mutation
• Protease Nexins
• Receptors, Cell Surface