Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Effects of A21G Mutation on Transmembrane Amyloid Beta (11-40) Trimer: An In Silico Study.

The journal of physical chemistry. B - 14 Sept 2017

Ngo Son Tung, Nguyen Minh Tung, Nguyen Nguyen Thanh, Vu Van V

Abstract excerpt

Familial Alzheimer's disease (FAD) is passed down in family, which account for 2-3% of about 40 million AD cases worldwide. The Flemish (A21G) mutant of amyloid β (Aβ) exhibits unique properties among all hereditary mutants of FAD, including the lowest aggregation rate. Recent studies showed that Aβ oligomers play a key role in Alzheimer's disease (AD) pathogenesis. They could insert themselves in brain cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Hydrogen Bonding
Share to Lipid Bilayers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Peptide Fragments

Share to Protein Folding

Share to Protein Multimerization

Share to Thermodynamics

Source

Identifiers

PMID: 28817283
DOI: 10.1021/acs.jpcb.7b05906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Effects of A21G Mutation on Transmembrane Amyloid Beta (11-40) Trimer: An In Silico Study.PMID 28817283Read ↗

Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide.Semantic proximity Read ↗

Impact of the mutation A21G (Flemish variant) on Alzheimer's beta-amyloid dimers by molecular dynamics simulations.Semantic proximity Read ↗

Impact of A2T and D23N Mutations on Tetrameric Aβ42 Barrel within a Dipalmitoylphosphatidylcholine Lipid Bilayer Membrane by Replica Exchange Molecular Dynamics.Semantic proximity Read ↗

Stability of Aβ11-40 Trimers with Parallel and Antiparallel β-Sheet Organizations in a Membrane-Mimicking Environment by Replica Exchange Molecular Dynamics Simulation.Semantic proximity Read ↗

Structural analysis of oligomeric and protofibrillar Aβ amyloid pair structures considering F20L mutation effects using molecular dynamics simulations.Semantic proximity Read ↗

Molecular insights into the effect L17A/F19A double mutation on the structure and dynamics of Aβ40 : A molecular dynamics simulation study.Semantic proximity Read ↗

Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.Semantic proximity Read ↗

Effect of Piedmont mutation (L34V) on the structure, dynamics, and aggregation of Alzheimer's Aβ40 peptide.Semantic proximity Read ↗

Factors influencing compact-extended structure equilibrium in oligomers of aβ1-40 peptide--an ion mobility mass spectrometry study.Semantic proximity Read ↗

Impact of A2V Mutation and Histidine Tautomerism on Aβ42 Monomer Structures from Atomistic Simulations.Semantic proximity Read ↗

Structural heterogeneity in familial Alzheimer's disease mutants of amyloid-beta peptides.Semantic proximity Read ↗

Impact of the Rat R5G, Y10F, and H13R Mutations on Tetrameric Aβ42 β-Barrel in a Lipid Bilayer Membrane Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.